Beta-thalassaemia: ARMS PCR TECHNIQUE
ARMS PCR TECHNIQUE
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Beta thalassaemia is a fairly common blood disorder worldwide. Thousand of infants with beta thalassaemia are born each year .Mutation in the HBB gene cause the beta thalassaemia.This gene provides instruction for making beta globin. Some mutation HBB gene prevents production of beta globin and some mutation provides less production of beta globulin. A lack of beta globin leads to reduced amount of functional haemoglobin. Without sufficient haemoglobin RBCs donot develop normally, causing a sortage of mature RBC. The low number of mature RBC leads to anemia and other associated health problem....
Beta thalassaemia is a fairly common blood disorder worldwide. Thousand of infants with beta thalassaemia are born each year .Mutation in the HBB gene cause the beta thalassaemia.This gene provides instruction for making beta globin. Some mutation HBB gene prevents production of beta globin and some mutation provides less production of beta globulin. A lack of beta globin leads to reduced amount of functional haemoglobin. Without sufficient haemoglobin RBCs donot develop normally, causing a sortage of mature RBC. The low number of mature RBC leads to anemia and other associated health problem.Clinically there is not any drug that can cure thalassaemia. Bone marrow transplantation is the only cure for thalassaemia. All thalassaemia patients are susceptible to health complications that involved the spleen and gall stones.
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