Cellular Signal Processing - Marks, Friedrich; Klingmüller, Ursula; Müller-Decker, Karin

Cellular Signal Processing

An Introduction to the Molecular Mechanisms of Signal Transduction

Friedrich Marks Ursula Klingmüller Karin Müller-Decker 

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Cellular Signal Processing

Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease.


  • Abmessung: 277mm x 217mm x 40mm
  • Gewicht: 1260g
  • ISBN-13: 9780815342151
  • ISBN-10: 0815342152
  • Best.Nr.: 25664309
Friedrich Marks, PhD, is Professor of Biochemistry at the University of Heidelberg and Emeritus Department head, German Cancer Research Center. Dr. Marks has been teaching biochemistry, in particular signal transduction, for more than 30 years. His research has focused on the role of signaling reactions in tumor development. Ursula Klingmuller, PhD, is a lecturer at the University of Heidelberg and Head of the Systems Biology of Signal Transduction Division, German Cancer Research Center. Dr. Klingmuller's research focuses on systems biology of signal transduction and dynamic pathway modeling. Karin Muller-Decker, PhD, is a lecturer at the University of Heidelberg and Head of the Tumor Models Units, German Cancer Research Center. Dr. Muller-Decker is conducting pioneering work on eicosanoid signaling in tumor development.
1. The "Brain of the Cell": Data Processing by Protein Networks
2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
3. Evolution of Cellular Data Processing
4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
5. Signal Transduction by Receptors with Seven Transmembrane Domains
6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
8. Gene Transcription: The Ultimate Target of Signal Transduction
9. Signals Controlling mRNA Translation
10. Signal Transduction by Small G-proteins: The Art of Molecular Targeting
11. Mitogen-activated Protein Kinase and Nuclear Factor kss Modules
12. Cancer and Regulation of Cell Division
13. Signal Transduction by Proteolysis and Programmed Cell Death
14. Signal Transduction by Ions
15. Sensory Signal Processing
16. Signaling at Synapses: Neurotransmitters and Their Receptors
17. Putting Together the Pieces: The Approach of Systems Biology