Bertil Hille

Ionic Channels of Excitable Membranes

• Gebundenes Buch

Produktbeschreibung

Published by Sinauer Associates, an imprint of Oxford University Press.Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand theirarchitecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellularsignaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has longbeen the recognized authoritative overview of this field used by all neuroscientists.

Produktdetails

• Verlag: Oxford University Press / Sinauer Associates
• 3. Aufl.
• Seitenzahl: 814
• Erscheinungstermin: 30. August 2001
• Englisch
• Abmessung: 241mm x 204mm x 36mm
• Gewicht: 1534g
• ISBN-13: 9780878933211
• ISBN-10: 0878933212
• Artikelnr.: 22534660

Autorenporträt

Bertil Hille

Inhaltsangabe

PART I.- Classical biophysics of the squid giant axon.- The superfamily of voltage-gated channels.- Voltage-gated calcium channels.- Potassium channels and chloride channels.- Ligand-gated channels of fast chemical synapses.- Modulation, slow synaptic action, and second messengers.- Sensory transduction and excitable cells.- Calcium dynamics, epithelial transport, and intercellular coupling.- PART II.- Elementary properties of ions in solution.- Elementary properties of pores.- Counting channels.- Structure of channel proteins.- Selective permeability: Independence.- Selective permeability: Saturation and binding.- Classical mechanisms of block.- Structure-function studies of permeation and block.- Gating mechanisms: Kinetic thinking.- Gating: Voltage sensing and inactivation.- Modification of gating in voltage-sensitive channels.- Cell biology and channels.- Evolution and origins.

Rezensionen

The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe." Steven A. N. Goldstein, Cell