Gary Walsh

Pharmaceutical Biotechnology

Concepts and Applications

• Broschiertes Buch

Produktbeschreibung

Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products.
_ introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science
_ an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students
_ includes specific 'product category chapters' focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products.
_ entire chapter devoted to the principles of genetic engineering and how these drugs are developed.
_ includes numerous relevant case studies to enhance student understanding
_ no prior knowledge of protein structure is assumed

Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14501245000
• 1. Auflage
• Seitenzahl: 504
• Erscheinungstermin: 1. September 2007
• Englisch
• Abmessung: 247mm x 190mm x 33mm
• Gewicht: 1075g
• ISBN-13: 9780470012451
• ISBN-10: 0470012455
• Artikelnr.: 22580193

Autorenporträt

Dr Gary Walsh, Chemical and Environmental Science Department, University of Limerick, Republic of Ireland.

Inhaltsangabe

1 Pharmaceuticals, Biologics and Biopharmaceuticals 1.1 Introduction to
pharmaceutical products 1.2 Biopharmaceuticals and pharmaceutical
biotechnology 1.3 History of the pharmaceutical industry 1.4 The age of
biopharmaceuticals 1.5 Biopharmaceuticals: current status and future
prospects Further reading 2 Protein Structure 2.1 Introduction 2.2 Overview
of protein structure 2.3 Higher level structure 2.4 Protein stability and
folding 2.5 Protein post-translational modification Further reading 3 Gene
Manipulation and Recombinant DNA Technology 3.1 Introduction 3.2 Nucleic
acids: function and structure 3.3 Recombinant production of therapeutic
proteins 3.4 Classical gene cloning and identification Further reading 4
The Drug Development Process 4.1 Introduction 4.2 Discovery of
biopharmaceuticals 4.3 The impact of genomics and related technologies upon
drug discovery 4.4 Gene chips 4.5 Proteomics 4.6 Structural genomics 4.7
Pharmacogenetics 4.8 Initial product characterization 4.9 Patenting 4.10
Delivery of biopharmaceuticals 4.11 Preclinical studies 4.12
Pharmacokinetics and pharmacodynamics 4.13 Toxicity studies 4.14 The role
and remit of regulatory authorities 4.14 Conclusion Further reading 5
Sources and Upstream Processing 5.1 Introduction 5.2 Sources of
biopharmaceuticals 5.3 Upstream processing Further reading 6 Downstream
Processing 6.1 Introduction 6.2 Initial product recovery 6.3 Cell
disruption 6.4 Removal of nucleic acid 6.5 Initial product concentration
6.6 Chromatographic purification 6.7 High-performance liquid chromatography
of proteins 6.8 Purification of recombinant proteins 6.9 Final product
formulation Further reading 7 Product Analysis 7.1 Introduction 7.2
Protein-based contaminants 7.3 Removal of altered forms of the protein of
interest from the product stream 7.4 Detection of protein-based product
impurities 7.5 Immunological approaches to detection of contaminants 7.6
Endotoxin and other pyrogenic contaminants Further reading 8 The Cytokines:
The Interferon Family 8.1 Cytokines 8.2 The interferons 8.3 Interferon
biotechnology 8.4 Conclusion Further reading 9 Cytokines: Interleukins and
Tumour Necrosis Factor 9.1 Introduction 9.2 Interleukin-2 9.3 Interleukin-1
9.4 Interleukin-11 9.5 Tumour necrosis factors Further reading 10 Growth
Factors 10.1 Introduction 10.2 Haematopoietic growth factors 10.3 Growth
factors and wound healing Further reading 11 Therapeutic Hormones 11.1
Introduction 11.2 Insulin 11.3 Glucagon 11.4 Human growth hormone 11.5 The
gonadotrophins 11.6 Medical and veterinary applications of gonadotrophins
11.7 Additional recombinant hormones now approved 11.8 Conclusion Further
reading 12 Recombinant Blood Products and Therapeutic Enzymes 12.1
Introduction 12.2 Haemostasis 12.3 Anticoagulants 12.4 Thrombolytic agents
12.5 Enzymes of therapeutic value Further reading 13 Antibodies, Vaccines
and Adjuvants 13.1 Introduction 13.2 Traditional polyclonal antibody
preparations 13.3 Monoclonal antibodies 13.4 Vaccine technology 13.5
Adjuvant technology Further reading 14 Nucleic-Acid- and Cell-Based
Therapeutics 14.1 Introduction 14.2 Gene therapy 14.3 Vectors used in gene
therapy 14.4 Gene therapy and genetic disease 14.5 Gene therapy and cancer
14.6 Gene therapy and AIDS 14.7 Antisense technology 14.8 Oligonucleotide
pharmacokinetics and delivery 14.9 Aptamers 14.10 Cell- and tissue-based
therapies 14.11 Conclusion Further reading Index