Plants produce a huge array of natural products (secondary
metabolites). These compounds have important ecological functions,
providing protection against attack by herbivores and microbes and
serving as attractants for pollinators and seed-dispersing agents.
They may also contribute to competition and invasiveness by
suppressing the growth of neighboring plant species (a phenomenon
known as allelopathy). Humans exploit natural products as sources
of drugs, flavoring agents, fragrances and for a wide range of
other applications. Rapid progress has been made in recent years in
understanding natural product synthesis, regulation and function
and the evolution of metabolic diversity. It is timely to bring
this information together with contemporary advances in chemistry,
plant biology, ecology, agronomy and human health to provide a
comprehensive guide to plant-derived natural products.
Plant-derived natural products: synthesis, function and application
provides an informative and accessible overview of the different
facets of the field, ranging from an introduction to the different
classes of natural products through developments in natural product
chemistry and biology to ecological interactions and the
significance of plant-derived natural products for humans. In the
final section of the book a series of chapters on new trends covers
metabolic engineering, genome-wide approaches, the metabolic
consequences of genetic modification, developments in traditional
medicines and nutraceuticals, natural products as leads for drug
discovery and novel non-food crops.
From the reviews: "This compilation of 25 review articles begins with a comprehensive introduction to the structures, biological activities, and applications of the major classes of terrestrial and marine plant-derived natural products. ... the book as a whole would have more utility to professionals wishing to increase their general knowledge of these topics. All of the articles are written articulately, and ... with an extensive bibliography for those who wish to consult the primary literature. Summing Up: Recommended. Upper-division undergraduates, graduate students, and professionals." (D. L. Jacobs, Choice, Vol. 47 (7), March, 2010)
Professor Anne Osbourn is Head of the Department of Metabolic Biology at the John Innes Centre, Norwich, UK, where she runs a research programme on plant-derived natural products. Her research is focused on the synthesis and function of plant-derived natural products and on mechanisms underpinning metabolic diversification. Professor Virginia Lanzotti is associate professor of organic chemistry at University of Molise, Campobasso, Italy and Meetings Secretary of the Phytochemical Society of Europe (PSE). Her research is focused on the stereostructure of natural products, drug discovery, food chemistry, and soil organic matter phytotoxicity. Winner of the 2003 PSE-Pierre Fabre award for excellence in phytochemistry.
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Preface.- The chemical composition of plants: Introduction to the different classes of natural products.- Natural products produced by marine plants/plants growing in other "different" habitats.- Natural variation/plant breeding.- Methods for analysis.- Ethnobotany.- Secondary metabolite biosynthesis: Introduction to the different classes of biosynthetic enzymes.- Structural analysis of biosynthetic enzymes.- Pathway elucidation.- Hormones, lipids, and signaling.- Regulators of natural product synthesis.- Metabolite channeling, protein complexes.- Glucosylation of secondary metabolites and xenobiotics.- Transport and release.- Links with growth and development.- Evolution of natural product pathways.- Biological activity: Biological activity effects on cells yeast, plants, animals, chemical genomics.- Role of natural products in nature pest and pathogen resistance.- Role of natural products in nature.- Carbohydrate signaling molecules.- Allelopathy.- Anticancer/disease prevention epidemiology and function.- Natural products and human receptors.- Flavors and fragrances.- New trends: Bioengineering.- Genome-wide approaches.- GM and substantive equivalence.- Traditional medicines and nutraceuticals.- Natural products as leads for drug discovery.- Novel non food crops.- Index.