Fluorine in Medicinal Chemistry and Chemical Biology

Fluorine in Medicinal Chemistry and Chemical Biology

The extraordinary potential of fluorine-containing biologically relevant molecules in biology, medicinal chemistry, and medical applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is expanding its biomedical frontiers. This book contains comprehensive reviews on cutting-edge developments and future prospects of fluorine in bioorganic and medicinal chemistry. It is essential for researchers who want to take advantage of the use of fluorine in biomedical research, from rational drug design, theory and synthesis to the use of fluorine labels as probes in metabolic study, protein engineering, and clinical diagnosis.

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IWAO OJIMA, PhD, is Distinguished Professor of Chemistry at the State University of New York at Stony Brook. He is also an Arthur C. Cope Scholar (ACS), a Guggenheim Fellow, and a Fellow of the American Association for the Advancement of Science.

Inhaltsangabe

Introduction
Chapter 1 "Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology" by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima
Medicinal Chemistry
Chapter 2 "Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent" by Yasushi Matsumura
Chapter 3 "Fluorinated conformationally restricted glutamate analogs for CNS drug discovery and development" by Atsuro Nakazato
Chapter 4 "Fluorinated Inhibitors of Matrix Metalloproteinases" by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda
Chapter 5 "Fluoro-Taxoid Anticancer Agents" by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima
Chapter 6 "Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability"by Jean-Pierre Bégué, Danièle Bonnet-Delpon
Chapter 7 "Synthesis and Biological Activity of Fluorinated Nucleosides" by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi
Synthetic methods for medicinal chemistry and chemical biology
Chapter 8 "Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-Containing Building Blocks" by Wei-Dong Meng and Feng-Ling Qing
Chapter 9 "Recent Advances in the Syntheses of Fluorinated Amino Acids" by Kenji Uneyama
Chapter 10 "Fluorinated Moieties for Replacement of Amide and Peptide Bonds" by Takeo Taguchi and Hikaru Yanai
Chapter 11 "Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery" by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong
Chapter 12 "gem-Difluorocyclopropanes as key building blocks for novel biologically active molecules" by Toshiyuki Itoh
Chapter 13 "Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products" by Wei Zhang
Chapter 14 "Fluorine-18 Radiopharmaceuticals" by Michael R. Kilbourn and Xia Shao
Applications of fluorinated amino acids and peptides to chemical biology and pharmacology
Chapter 15 "Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins" by Mario Salwiczek, Toni Vagt and Beate Koksch
Chapter 16 "Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology" by He Meng, Ginevra A. Clark, and Krishna Kumar
Chapter 17 "Effects of Fluorination on the Bioorganic Properties of Methionine" by John F. Honek
Chapter 18 "Structure analysis of membrane-active peptides using 19F-labeled amino acids and solid state NMR" by Parvesh Wadhwani and Erik Strandberg
Chapter 19 "Metabolism of Fluorine-containing Drugs using in vivo Magnetic Resonance Spectroscopy" by Erika Schneider
Appendix
"FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine" by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima